Products

AVICEL PH
Microcrystalline Cellulose USP/NF, EP, JP

Avicel PH, FMC’s innovator brand of microcrystalline cellulose, is a purified, partially depolymerized alpha-cellulose made by acid hydrolysis of specialty wood pulp. The process of polymerization involves high levels of quality and stringency.

Avicel PH’s unique properties - superior compactibility, drug carrying capacity and rapid disintegration make it the excipient of choice in direct compression applications. When used in the wet granulation process, the risk of over-granulation is reduced, screen blockage is avoided and uniform, rapid drying is promoted. The distinct properties of this excipient also benefit the dry granulation processes of roller compaction and slugging. Avicel PH is an excellent extrusion-spheronization binder and its inclusion in capsule formulations improves flow, facilitates plug formation and aids capsule disintegration.

With the development of differentiated grades, Avicel PH remains an indispensible formulation tool, boosting productivity and meeting tough formulation challenges.

Grade

Particle Size
(µm)

Moisture Content
(%)

Applications

Avicel PH-101

 

50

 

3.0 - 5.0

 

Conventional grade for wet and dry granulation

 

Avicel PH-102

 

100

 

3.0 - 5.0

 

Improves flow in direct compression, dry phase of wet granulation and dry granulation

 

Avicel PH-103

 

50

 

NMT 3.0

 

Well suited for moisture sensitive actives

 

Avicel PH-105

 

20

 

NMT 5.0

 

Extra-fine particle size, used for direct compression of materials which are coarse or hard to compress

 

Avicel PH-112

 

100

 

NMT 1.5

 

Lowest moisture content and is best suited for direct compression of moisture sensitive actives

 

Avicel PH-113

 

50

 

NMT 2.0

 

Improves product stability, particularly of formulations using moisture sensitive actives

 

Avicel PH-200

 

200

 

2.0 - 5.0

 

Largest particle size, enhances flow in direct compression and dry granulation whilst maintaining high levels of compressibility with minimum weight variation and content uniformity

 

Avicel PH-200 LM

 

200

 

NMT 1.5

 

Largest particle size with lowest moisture content, allowing for better flow rate than Avicel PH-112. Improvised grade for direct compression of moisture sensitive actives

 

Avicel PH-301

 

50

 

3.0 - 5.0

 

High bulk density grade, for manufacturing of small tablets. Reduces powder stratification and tablet weight variation by allowing efficient mixing

 

Avicel PH-302

100

3.0 - 5.0

High bulk density grade with larger particle size, used for production of thin tablets especially in high dose drug formulations. Avoids powder segregation and achieves good flow rates

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