Products

SHIN-ETSU AQOAT
Hypromellose Acetate Succinate USP/NF, JP

This excipient is a novel, enteric coating polymer manufactured from highly purified pulp involving introduction of acetyl and succinoyl groups into the hydroxyl backbone of hypromellose.

The characteristics of Shin-Etsu Aqoat allow its use in different coating techniques such as aqueous, solvent based, ammonia neutralization and dry / deposition coating. It is also recommended in solid dispersions to enhance the bioavailability of poorly soluble drugs as well as in the design of controlled-release dosage forms for targeting drug release to specific gastrointestinal sites.

Various grades of Shin-Etsu Aqoat are available which differ in chemical substitution levels and particle sizes,which govern their use in either aqueous coating, organic coating, or hot melt extrusion process.

Grade

Description

Applications

Mean Particle
Size

Dissolving

pH

Acetyl (%) /
Succinoyl (%)

AQOAT AS-LF

5 μm

≥ 5.5

8/15

Micronized grade for aqueous and dry coating

AQOAT AS-MF

≥ 6.0

9/11

AQOAT AS-HF

≥ 6.5

12/7

AQOAT AS-LG

1 mm

≥ 5.5

8/15

Granular grade for solvent based coating

AQOAT AS-MG

≥ 6.0

9/11

AQOAT AS-HG

≥ 6.5

12/7

AQOAT AS-LMP

~ 300 μm ≥ 5.5 8/15 Median particle size grade especially suited for hot melt extrusion process for solid dispersion formulations

AQOAT AS-MMP

≥ 6.0 9/11

AQOAT AS-HMP

≥ 6.5 12/7

This browser is not supported. For a better experience on Signet, update your browser.