Products

L-HPC
Low-Substituted Hydroxypropyl Cellulose USP/NF, EP, JP

L-HPC is a low-substituted hydroxypropyl ether of cellulose. It is non-ionic, less reactive to active ingredients, insoluble in water and alcohol but swells in water by holding water molecules around hydroxypropyl groups that are distributed on the cellulose backbone. L-HPC is widely used as a dual-functionality excipient (binder-disintegrant) for tablets, granules or other pharmaceutical solid dosage forms depending on its particle size and substituent content. Tablets containing L-HPC disintegrate into very fine individual particles, thus resulting in rapid drug dissolution.

Shin-Etsu has launched new ‘L-HPC NBD’ grades with different particle morphology that are designed to significantly improve flow properties. It also enhances binding and disintegration capability.

Grade

Description

Applications

Mean
Particle Size
(μm)

Hydroxypropoxy
Content
(%)

Particle

Morphology

L-HPC LH-11

55

11

Highly fibrous

Direct compression, anticapping

L-HPC LH-21

45

11

Moderately fibrous

Dry mixing, wet granulation

L-HPC LH-22

8

Allows for better disintegration due to lower hydroxypropoxy content

L-HPC LH-31

20

11

Micronized

Pellet extrusion, layering

L-HPC LH-32

8

L-HPC LH-B1

55

11

Non-fibrous

Fluidized-bed granulation, direct compression for high load formulations

L-HPC NBD-020

45

14

Non-fibrous and smaller primary particles

Higher binding capability in wet granulation

L-HPC NBD-021

11

Direct compression and wet granulation

L-HPC NBD-022

8

Quick swelling, especially for orodispersible tablets

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